Two-photon holographic optogenetics

Light up the brain with flexible femtosecond lasers! The aeroPULSE FS laser is an essential photostimulation tool in any optogenetics lab!

Neuroscientists make neurons light up in the brain using lasers

Optimal laser solutions for neuroscientists

See the brain in a new light!

Stimulating neurons helps us understand brain functions, their connection to behavior, and the origins of neurological diseases. Two-photon holographic optogenetics makes it possible to stimulate tens to hundreds of neurons with high spatial and temporal precision.

The pulse energy you need depends on the organism you study—mice, flies, worms, or zebrafish—and the number of neurons you want to stimulate. Choosing a cost-effective femtosecond laser with the appropriate pulse energy and power for your experiments is essential.

The aeroPULSE FS series allows researchers to select a laser with the right pulse energy and repetition rate. This approach ensures sufficient power for your experiments and helps avoid unnecessary costs often associated with purchasing lasers with too much excess power.

Flexibility and precision

Two-photon holographic optogenetics is the most effective among the existing optical stimulation methods. It enables exact and minimally invasive stimulation of neurons in the brain.

Different stimulation processes—whether in mice or flies or based on the number of neurons stimulated—require varying amounts of pulse energy. Selecting a cost-effective femtosecond laser is essential to ensure the appropriate pulse energy and power are available for the specific stimulation scheme.

Our aeroPULSE FS series provides neuroscientists with the flexibility to choose a laser with the precise pulse energy and repetition rate required to control the desired number of neurons for their specific application. This approach helps remove the risk of tissue damage and avoids unnecessary costs historically associated with unused power.

The aeroPULSE FS laser portfolio offers versatile power options and guarantees reliable, on-demand performance.

Read the application note to learn more.

Get a 2-minute intro to the aeroPULSE FS50

Which laser matches your needs and budget?

aeroPULSE FS50

With >50 W average power and >40 µJ pulse energy, the aeroPULSE FS50 is an ideal solution for stimulating large numbers of neurons across various stimulation schemes.

aeroPULSE FS10

With >10 W average power and >20 µJ pulse energy, the compact air-cooled aeroPULSE FS10 is a good choice for stimulating tens of neurons.

Compare the aeroPULSE FS lasers

Choose model:
aeroPULSE FS10
aeroPULSE FS50
Center wavelength
1030 ± 5 nm
1030 ± 5 nm
Power
>10 W
>50 W
Max. pulse energy
>20 µJ
>40 µJ
Repetition rate
Up to 20 MHz
Up to 50 MHz
Pulse duration
<350 fs
<400 fs
Beam diameter
1.0 ± 0.15 nm
2.0 ± 0.5 nm
Spatial mode, fundamental
M2 ≤1.2
M2 ≤1.2
Beam asymmetry/ellipticity
<15%
<15%
Power stability (8 hours), RMS
<0.5%
<0.5%
Polarization – linear, PER
>25 dB
>25 dB
Cooling
Air
Water